| There are a lot of studies that demonstrate taking daily Vitamin D supplements reduces the likelihood of lung infections. Moreover, the first double blind clinical trial on Vitamin D and COVID-19 was published [0] which had astonishing results: N=76 Percentage admitted to ICU: 50% -> 2% Deaths: 8% -> 0% I suggest you read the paper for the full picture, or to watch the analysis of Dr John Cambell [1] There’s more and more studies like this that demonstrate that Vitamin D helps prevent bad outcomes. In other words: people who are Vitamin D deficient are much more likely to develop severe complications after contracting COVID-19. 42% of Americans are Vitamin D deficient. For African Americans that percentage is 82%, because darker skin makes Vitamin D more slowly. In Europe we are going through a 2nd wave of infections, yet the death-rate is much lower than the first wave. This could be explained by the lower Vitamin D deficiency in most people thanks to the summer. For what it’s worth, I am taking 25mcg/day of Vitamin D supplement. They are dirt cheap (5Eur for 300 days). Dr John Cambell is taking 50mcg and an email from Dr Fauci revealed that he is taking 150mcg/day [1]. So even if you get exposure to sunlight, I would suggest looking into taking a supplement. Why the main media/government channels don’t talk about this more is baffling and potentially criminal. Maybe because there’s no money to be made from Vitamin D because there are no patents? [0] https://www.sciencedirect.com/science/article/pii/S096007602... [1] https://youtube.com/watch?v=V8Ks9fUh2k8 |
1. Statistically significant difference in patients with documented hypertension in the no-vitamin-d group (p value 0.002, 15 vs 11 patients)
2. 2:1 randomization, reducing statistical power. They do not document the sample size needed from a power analysis looking for power > 0.80. They basically assumed that twice as many people without vitamin D would end up in ICU, when in reality 13x as many people ended up ICU. In general, I wish we could have a larger sample size for studies like this, but I know it isn't practical.
3. Biggest for me is no baseline serum vitamin D level recorded, just an assumption that patients selected were overall vitamin D deficient based on population. Seems like a simple enough test that could have been run as a send out test (no need to have the level during hospitalization, just for data gathering purposes).
4. Not placebo controlled, would have helped as placebo effect is real. For all we know, giving the research medication could have meant that the patient received more care and supervision, potentially aiding in their hospital course.