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by claudeganon
2164 days ago
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This is addressed in the Nature article I linked. They compare SARS/MERS immunity to COVID-19 and find different results: >Sustained IgG levels were maintained for more than 2 years after SARS-CoV infection. Antibody responses in individuals with laboratory-confirmed MERS-CoV infection lasted for at least 34 months after the outbreak. Recently, several studies characterizing adaptive immune responses to SARS-CoV-2 infection have reported that most COVID-19 convalescent individuals have detectable neutralizing antibodies, which correlate with the numbers of virus-specific T cells. In this study, we observed that IgG levels and neutralizing antibodies in a high proportion of individuals who recovered from SARS-CoV-2 infection start to decrease within 2–3 months after infection. In another analysis of the dynamics of neutralizing antibody titers in eight convalescent patients with COVID-19, four patients showed decreased neutralizing antibodies approximately 6–7 weeks after illness onset. One mathematical model also suggests a short duration of immunity after SARS-CoV-2 infection. Together, these data might indicate the risks of using COVID-19 ‘immunity passports’ and support the prolongation of public health interventions, including social distancing, hygiene, isolation of high-risk groups and widespread testing. So the rate of decrease is already greater than SARS and MERS under this initial investigation. I agree that we don't know the rate or duration of immunity, but nothing so far seems to point in the direction you keep emphasizing or justifies your confidence. I actually do hope immunity ends up being longer lasting, but what I "hope" is irrelevant. I don't know that herd immunity is a dirty word, but might, for COVID, be being deployed dangerously and pseudo-scientifically. The "natural phenomenon" you refer to does not occur in all cases for all diseases. It's not callousness unless you're explicitly denying that reality and justifying excess death and illness on a dynamic which may not even be in play. |
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What's an example of an infectious disease that the body can fight off that does not result in herd immunity? (so, herpes and aids don't count because the body doesn't fight them off whereas we KNOW that the body fights off SARS-like diseases)
As far as reinfection is concerned, T-cells are more relevant. I am aware that antibody response fades sooner for SARS-CoV-2.
("SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls")[https://www.nature.com/articles/s41586-020-2550-z] - Published: 15 July 2020
* Here, we first studied T cell responses to structural (nucleocapsid protein, NP) and non-structural (NSP-7 and NSP13 of ORF1) regions of SARS-CoV-2 in COVID-19 convalescents (n=36). In all of them we demonstrated the presence of CD4 and CD8 T cells recognizing multiple regions of the NP protein. We then showed that SARS-recovered patients (n=23) still possess long-lasting memory T cells reactive to SARS-NP 17 years after the 2003 outbreak, which displayed robust cross-reactivity to SARS-CoV-2 NP.
* Surprisingly, we also frequently detected SARS-CoV-2 specific T cells in individuals with no history of SARS, COVID-19 or contact with SARS/COVID-19 patients (n=37)
> It's not callousness unless you're explicitly denying that reality and justifying excess death and illness on a dynamic which may not even be in play.
Again, the excess death is the deaths caused by lockdown, not the deaths caused by a highly infectious respiratory virus. All highly infectious respiratory viruses are dealt with the same way: acquiring population immunity. Vaccines are just a way to achieve that more cheaply, but because we do not currently have a vaccine it does not make sense to try to "stop, drop and roll" until we have one. Especially because, speaking for the US, we are on track to hit population immunity before we ever get one.