Is it a good idea to take any of these - alcohol, Marijuana, LSD, mushrooms - with antidepressants? That is, if you're on medication, should you stay away from all recreational drug use?
It is imperative that you do not combine psychedelics with antidepressants! This can lead to dangerous side effects / behaviors! If you take a combination of drugs this is even more important to heed.
The proper path is to wean yourself off of the antidepressants for the experience, and then only undertake the experience with an experienced sitter or guide.
Psilocybins effect is enhanced by MAOI and decreaces by SSRIs. LSD effects are decreased by both. With other other psychedelics you have to be a bit carefull.
You probably think of MDMA and MAOIs, this would be a dangerous combination.
It is worth investigating with caution the option of using recreational drugs alongside antidepressant medication.
I take the SSRI Fluoxetine (Prozac) and have tried numerous psychedelic drugs while on that prescription drug. Before doing so I checked with my psychiatrist who did not believe there would be a great risk.
My experience has generally been that psychedelics work (with the exception of MDMA) and there are no drawbacks to using them while on an SSRI. Of course, psychedelics do have risks and educated, responsible use is appropriate.
The proper path is to wean yourself off of the antidepressants for the experience, and then only undertake the experience with an experienced sitter or guide.