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by sibeliuss 2400 days ago
It is imperative that you do not combine psychedelics with antidepressants! This can lead to dangerous side effects / behaviors! If you take a combination of drugs this is even more important to heed.

The proper path is to wean yourself off of the antidepressants for the experience, and then only undertake the experience with an experienced sitter or guide.
2 comments
xorfish 2400 days ago
https://wiki.tripsit.me/images/3/3a/Combo_2.png

Psilocybins effect is enhanced by MAOI and decreaces by SSRIs. LSD effects are decreased by both. With other other psychedelics you have to be a bit carefull.

You probably think of MDMA and MAOIs, this would be a dangerous combination.

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mirimir 2400 days ago
Yes, MAOI dramatically increase and prolong effects of DMT.

And indeed, that's what ayahuasca (aka yage) is.

Plus various mushrooms and other psychoactive stuff, depending on the preferences of the curandeiro/a (shaman) and the intended outcome.

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Frondo 2400 days ago
It absolutely depends on the anti-depressant.

SSRIs, do not mix.

NDRIs, lots of people report they're fine.

Hopefully we'll get better data on what other chemicals are okay to mix as these things slowly become permitted to be the subjects of study.

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