I’m increasingly of the opinion that nuclear for space should be mined and built in space. Just launch the infrastructure needed to bootstrap the process.
I'm all for that in the long run, but that's in the long run. Especially with Orion Drives they're too dangerous to fly themselves off the Earth but too heavy to launch on something else so they're entirely impractical right now. But it would be cool if we could be launching them from the Moon in the 2080s.
And shipping up unrefined ore is also a bit of a ludicrous idea for mass reasons and the rocket equation alone. You do realize you can isolate a nuclear reactor core from explosions on rockets right? What catastrophic failures are you attempting to design your solution of avoiding a nuclear reactor around?
The moon's dust contains huge amounts of helium-3.
Which apparently is an amazing power source.
Also, why fission? We do have working fusion reactors. They are called hydrogen bombs. (The outer part, at least.) As long as you can keep the G forces low ...