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by meowface 2872 days ago
I don't think the root cause(es) of psychosis have really been determined yet. I think it's fair to say that since many drugs induce immediate psychosis, it's unlikely that pruned connections are the only cause.
2 comments

It’s pretty clearly D2-like receptors being overexcited, at least as far as cause and effect. Hence psychotic symptoms in stimulant users and a remission of psychosis in schizophrenic patients when on D2-blocking drugs.
D2 receptors are undoubtedly tied to many forms of psychosis, but their being the root cause is not yet proven.
Psychosis resulting from meth withdrawal has always suggested to me that it is an under-connected problem because presumably what happens during withdrawal is widespread "disconnection" resulting from a large decrease in synaptic sensitivity (caused by a flood of neurotransmitter, meth) and a steep drop in neurotransmitter activity once the meth is gone.
Stimulants shred the cells' mitochondria. Psychosis is a metabolic problem.