| Can Alzheimer's disease also be known as Type 3 diabetes? "Brain insulin resistance (diabetes) is very much like regular diabetes," de la Monte said. "Since the underlying problems continue to be just about the same, we believe that the development of new therapies would be applicable for all types of diabetes, including Alzheimer's disease, which we refer to as Type III diabetes." Suzanne M. de la Monte, Edward Re, Lisa Longato, Ming Tong. Dysfunctional Pro-Ceramide, ER Stress, and Insulin/IGF Signaling Networks with Progression of Alzheimer’s Disease. Journal of Alzheimer's Disease, June 22, 2012, supplement; DOI: 10.3233/JAD-2012-111728 Same author four years prior: "brain insulin resistance is sufficient to cause AD and that additional significant abnormalities, such as ongoing DNA damage and mitochondrial dysfunction, are required." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769828/ |
> Therefore, T2DM and obesity may contribute to, i.e., serve as cofactors of AD but by themselves are probably not sufficient to cause AD. Moreover, the findings in the T2DM/obesity model indicate the unlikelihood [emphasis here] that brain insulin resistance is sufficient to cause AD and that additional significant abnormalities, such as ongoing DNA damage and mitochondrial dysfunction, are required.