[MBCook]

I'm not seeing the problem you're describing on my device. I've got a 10.5" iPad Pro with the latest version of iOS 10. Safari page text, the text field I'm typing into, the search field on springboard, notes, and a random third-party app all render the same glyphs; the only differences are minor things like font size and weight.

[gfmio]

Ah, thx. It seems to work on Safari for me as well. However, it doesn't seem to work for Firefox and Chrome (which I used to initially test this) using the same settings. Shouldn't the browsers all have the same font lookup behaviour given the same font-family settings?

[Darsstar]

Interestingly enough Chrome renders it just fine in the tab name/title.

[gfmio]

True, I'm noticing that as well. It seems that some OS X system fonts (San Francisco?) are used for rendering in Safari by default as well as in various UI elements (Tab heading, Search bars, ...), but not in the Chrome or FF browser itself, even if you set the font family to System UI fonts.