[Capt-RogerOver]

Can you link of that evidence? In form of scientific studies (quality ones)? This is not a general "you can't prove your point, you don't have science". I'm actually interested. I have been looking for hard science in this area and have seen none that would back up your claims.

[48snickers]

I'm interested in this as well.

So far, all I've found is some research that artificially lowering LDL or raising HDL may not show clear correlation to lower heart disease risk- not quite the same thing as saying LDL isn't generally correlated to heart disease risk:

Broad overview:

  https://www.scientificamerican.com/article/cholesterol-conundrum/

Studies references (but not cited) in the article above:

  http://www.nejm.org/doi/full/10.1056/NEJMe0801608

  http://www.nejm.org/doi/full/10.1056/NEJMoa1107579

[SAI_Peregrinus]

http://blogs.sciencemag.org/pipeline/archives/2017/05/18/now...

The linked paper goes into more detail, of course. And this is only one drug, but there are quite a few other failures of similar type, though less dramatic, discussed in the "Cardiovascular Disease" section of his blog. He always links the original papers, but they're often paywalled or highly technical.