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by SAI_Peregrinus 3293 days ago
http://blogs.sciencemag.org/pipeline/archives/2017/05/18/now...

The linked paper goes into more detail, of course. And this is only one drug, but there are quite a few other failures of similar type, though less dramatic, discussed in the "Cardiovascular Disease" section of his blog. He always links the original papers, but they're often paywalled or highly technical.