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by TenOhms 3432 days ago
Before the article even begins it gives erroneous information: "Morphine is extracted from opium, a compound found in the seeds of the opium poppy."

Edit: The research looks interesting though.

4 comments

It looks like an issue with wording to me, i.e. they may have meant "can in theory be, but usually isn't compared to the high cost compared to lab synthesis", but oversimplified it.
Other way around, synthesis is more expensive (according to wikipedia). But the extraction from poppies doesn't need to involve opium as an intermediary (once again according to wikipedia).
Yeah, you're absolutely right; the DEA even sets import quotas. There are drugs where this is true, but I'm apparently remembering the wrong one.
Care to clarify what's erroneous?
The active compounds are not concentrated in the seeds. The seeds are even in the way of extraction of the opioids from the rest of the plant.

Also, Opium is not really a compound, it's a mixture (which is maybe getting pedantic, but it's ~8th grade science).

Correct, the seeds themselves are inert, the latex surrounding the seeds is what contains the opium.
It seems there are two processes in use, one uses opium as an intermediary, the other doesn't.

https://en.wikipedia.org/wiki/Morphine#Production

The latex used in India would seem to be opium (which is a dried latex obtained from the opium poppy)

https://en.wikipedia.org/wiki/Opium

Although may be present in the seeds in minute quantities, they extract it from the seed pod by scarring the pod and then letting it "bleed" (probably not the correct term) and harvesting it later.
Opium is a mixture of compounds, not a compound itself.
I've always wondered about the relationship between america's opiate habit and the afghan poppy harvest. The US army was burning millions (billions?) of dollars worth of poppies every year, to deny profit to the taliban. Could that not have been used to make pain pills? How do the incentives flow here?
There's no shortage of pain pills. GoodRX is a pharmacy benefit manager that doesn't collect any payments from users, it runs on marketing fees, so it gives some information about the real cost of drugs. Several weeks of Oxycodone costs $20 at the pharmacy:

https://www.goodrx.com/roxicodone

> Could that not have been used to make pain pills?

To my knowledge, the industry has moved away from poppies that produce morphine (they still technically grow p. somniferum, but a special cultivar with low morphine content to discourage theft).

Instead they extract the opioid compound thebaine, which is then converted to powerful name-brand pain meds. This is why they're called "semi-synthetic opioids", because they require thebaine as the primary ingredient.

So yes, those could have been used to produce pain meds the "old-school" way but I doubt they'd be of any use to western pharmaceutical companies.

> The US army was burning millions (billions?) of dollars worth of poppies every year, to deny profit to the taliban.

I'm not sure that's the whole story, if you look at the statistics then it rather looks like poppy production has increased since the US/NATO occupation [0], at least compared to the, very low, numbers in 2000.

Turkey is one example of a country that successfully managed to legalize their poppy production, but it's questionable if that approach would work just as well in Afghanistan [1].

[0]https://www.unodc.org/documents/crop-monitoring/Afghanistan/... (Page 14, Figure 2)

[1]http://www.tdpf.org.uk/blog/turkey%E2%80%99s-opium-trade-suc...

The United States gave the Taliban $43 million in 2011 in appreciation of their efforts to eradicate the Afghan poppy crop.

https://www.thenation.com/article/bushs-faustian-deal-taliba... http://www.nytimes.com/2001/05/20/world/taliban-s-ban-on-pop...

I think you may have meant 2001? Both links date to 2001 pre-9/11.
As I understand the talban were opposed to drugs and they did a good job of ensuring poppy was not grown in the country. (they had other problems, but aiding the illegal drug trade was not one)
The Taliban was destroying the opium crop and suppressing the trade. After the US toppled that regime, the opium business exploded.
1st sentence of wikipedia, "Morphine is a pain medication of the opiate type which is found naturally in a number of plants and animals."
Right, but the OP was interpreting the sentence to imply that that's where it comes from. Morphine medication is all synthesized.
Nope, otherwise farmers in Afghanistan wouldn't have switched to growing opium poppies en masse.

Apparently the main issue the OP had was with the seeds part.