[khed]

This is an excellent comment and reflects the current state of research.

There is good evidence for the efficacy of ketamine in treatment resistant depression.

The psychedelics are not well studied.

SSRIs are not useful and may be harmful.

ECT works but causes amnesia.

Most depression gets better on its own.

[Pigo]

I suffered from depression pretty much my entire 20's, and looking back it felt like the long line of anti-depressants I was prescribed exacerbated the situation. Eventually I changed how I live my life and started making baby steps towards improving myself. And I magically stopped being depressed. I have no doubt there are people out there that need help with medication. But I think the only thing that could have helped me was someone reaching out and showing me how to get out of my rut. But even then it would have been on me to make some changes and find out what makes me happy.

[mst]

Tianeptine has done wonders for me, but is a weird-ass tricyclic that may not work in any of the usual ways.

The side effect profile is sufficiently minimal that if it turns out I'm just a lucky beneficiary of a placebo effect, I really don't mind.