> Have you considered that post hoc is not necessarily proper hoc.
Disruption of the endocrine glands is on the drug safety information [1]:
Effects on the Hypothalmic-Pituitary-Adrenal Axis
Some patients receiving medroxyprogesterone acetate may
exhibit suppressed adrenal function. Medroxyprogesterone
acetate may have cortisol-like glucocorticoid activity
and provide negative feedback to the hypothalamus or
pituitary. This may result in decreased plasma cortisol
levels, decreased cortisol secretion, and low plasma ACTH
levels. The use of DEPO-PROVERA Sterile Aqueous
Suspension may, due to its cortisol-like glucocorticoid
activity, also produce Cushingoid symptoms such as weight
gain, edema/fluid retention, and facial swelling.
edit: p.s. Thanks for commenting, I'd never looked at Depo Provera's safety information before. Someone else had said that he thought that Depot-Provera's FDA approval, in spite of what's known about it, is a good example of 'Regulatory Capture'. Psychosis is associated with cortisol deficiency [2], so this safety information strongly supports my theory about the origin of my friend's mental health struggles.
Disruption of the endocrine glands is on the drug safety information [1]:
[1] http://www.fda.gov/Safety/MedWatch/SafetyInformation/ucm2323...edit: p.s. Thanks for commenting, I'd never looked at Depo Provera's safety information before. Someone else had said that he thought that Depot-Provera's FDA approval, in spite of what's known about it, is a good example of 'Regulatory Capture'. Psychosis is associated with cortisol deficiency [2], so this safety information strongly supports my theory about the origin of my friend's mental health struggles.
[2] https://www.jcu.edu.au/news/releases/2016/june/stress-hormon...