[tcj_phx]

> Have you considered that post hoc is not necessarily proper hoc.

Disruption of the endocrine glands is on the drug safety information [1]:

  Effects on the Hypothalmic-Pituitary-Adrenal Axis

  Some patients receiving medroxyprogesterone acetate may 
  exhibit suppressed adrenal function. Medroxyprogesterone 
  acetate may have cortisol-like glucocorticoid activity 
  and provide negative feedback to the hypothalamus or 
  pituitary. This may result in decreased plasma cortisol 
  levels, decreased cortisol secretion, and low plasma ACTH 
  levels. The use of DEPO-PROVERA Sterile Aqueous 
  Suspension may, due to its cortisol-like glucocorticoid 
  activity, also produce Cushingoid symptoms such as weight 
  gain, edema/fluid retention, and facial swelling.

[1] http://www.fda.gov/Safety/MedWatch/SafetyInformation/ucm2323...

edit: p.s. Thanks for commenting, I'd never looked at Depo Provera's safety information before. Someone else had said that he thought that Depot-Provera's FDA approval, in spite of what's known about it, is a good example of 'Regulatory Capture'. Psychosis is associated with cortisol deficiency [2], so this safety information strongly supports my theory about the origin of my friend's mental health struggles.

[2] https://www.jcu.edu.au/news/releases/2016/june/stress-hormon...