What if the license of the software you want to run is 100k per physical host? Then being able to run 2 or 4 instances on the same physical host makes the $2226 cost pretty insignificant.
If you have software that costs that much, you will want to run it on hardware optimized for that software. (Does it want lots of GPU cores? I/O? Raw computrons? Does it prefer more cores or more GHz/core?) Unless Amazon happens to have exactly what you want available, you'll be better off putting it in a lab or datacenter.
Maybe, maybe not. Just because software cost a lot does not mean it is super high performance. Some is awful php strung together hacks, but if it does what a customer wants - it may be worth 100k to them.