[dsr_]

If you have software that costs that much, you will want to run it on hardware optimized for that software. (Does it want lots of GPU cores? I/O? Raw computrons? Does it prefer more cores or more GHz/core?) Unless Amazon happens to have exactly what you want available, you'll be better off putting it in a lab or datacenter.

[brianwawok]

Maybe, maybe not. Just because software cost a lot does not mean it is super high performance. Some is awful php strung together hacks, but if it does what a customer wants - it may be worth 100k to them.