[vezzy-fnord]

"Dangerous" is too vague to be useful. There's plenty of legal, commercially produced opioids and opiates. Those have been well studied and have a variety of adverse reactions if not used delicately. However, they're perceived as "medicine" or "useful drugs" and hence do not have the same stigma.

[ethbro]

If "dangerous" is too vague, then "untested" is valid. You can absolutely get me on board with the "DEA/FDA limit testing of illegal substances" rebuttal, but you can't say the variety of illegal substances have been as well tested through customer dosage as something that currently goes to market.

[TeMPOraL]

I think the biggest advantage Big Pharma would have over the cartels and fly-by-night drug makers is that legitimate companies are held accountable to quality and safety standards, therefore you can be sure that you're buying a drug produced following a proper process and contains only what it's supposed to. A lot of deaths from (illegal) drug use is caused by impurities and not by the drug itself, and illicit actors don't have incentives to reduce them.