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1.
CRISPR tech selectively shreds cancer cells, including "undruggable" cancers (innovativegenomics.org)
348 points by gmays 3 hours ago | 90 comments
2.
I Am Not a Reverse Centaur (blog.miguelgrinberg.com)
72 points by ibobev 1 hour ago | 30 comments
3.
How to Setup a Local Coding Agent on macOS (ikyle.me)
49 points by kkm 1 hour ago | 12 comments
4.
Pirates, a naval warfare game inspired by Sid Meier's Pirates (piwodlaiwo.github.io)
46 points by iweczek 2 hours ago | 21 comments
5.
A PDF that changes based on how its read (sgaud.com)
67 points by SarthakGaud 2 hours ago | 30 comments
6.
Slightly reducing the sloppiness of AI generated front end (envs.net)
115 points by FergusArgyll 4 hours ago | 76 comments
7.
Malware developers added nuclear and biological weapons text to to their spyware (twitter.com)
107 points by marc__1 22 hours ago | 79 comments
8.
Looking Forward to Postgres 19: It's About Time (pgedge.com)
55 points by xngbuilds 2 hours ago | 17 comments
9.
A dumpster arrived behind my university's library (yalereview.org)
114 points by mooreds 4 hours ago | 90 comments
10.
Launch HN: BitBoard (YC P25) – Analytics Workspace for Agents (bitboard.work)
15 points by arcb 2 hours ago | 5 comments
11.
Where Did Earth Get Its Oceans? Maybe It Made Them Itself (quantamagazine.org)
66 points by ibobev 3 hours ago | 42 comments
12.
There Is Life Before Main in Rust (grack.com)
30 points by mmastrac 1 day ago | 8 comments
13.
Cosmodial Sky Atlas (killedbyapixel.github.io)
6 points by memalign 49 minutes ago | 1 comments
14.
AI agent bankrupted their operator while trying to scan DN42 (lantian.pub)
1300 points by xiaoyu2006 14 hours ago | 474 comments
15.
Introduction to UEFI HTTP(s) Boot with QEMU/OVMF (blog.yadutaf.fr)
34 points by jtlebigot 4 hours ago | 8 comments
16.
Keygen.music (keygen.music)
99 points by soupspaces 3 hours ago | 60 comments
17.
Law Enforcement's "Warrior" Problem (2015) (harvardlawreview.org)
24 points by bookofjoe 2 hours ago | 13 comments
18.
Hazel (YC W24) Is Hiring a Full Stack Engineer (ycombinator.com)
1 points by augustschen 5 hours ago
19.
Maxproof (arxiv.org)
110 points by ilreb 7 hours ago | 8 comments
20.
A Call to Action: Stop the FCC's KYC Regime (blog.lopp.net)
266 points by FergusArgyll 4 hours ago | 172 comments
21.
A Peter Thiel-Backed Tribunal Is Putting Journalists on Trial (hollywoodreporter.com)
10 points by cdrnsf 29 minutes ago | 1 comments
22.
WASI 0.3 (bytecodealliance.org)
192 points by mavdol04 5 hours ago | 78 comments
23.
I Won't Buy You a Coffee (hakkerman.eu)
23 points by speckx 32 minutes ago | 21 comments
24.
"Don't You Just Upload It to ChatGPT?" (correresmidestino.com)
80 points by speckx 1 hour ago | 78 comments
25.
Show HN: StackScope – I crawled over 40k indie launches to see what they ship (stackscope.dev)
26 points by datafreak_ 3 hours ago | 7 comments
26.
If you are asking for human attention, demonstrate human effort (tombedor.dev)
1380 points by jjfoooo4 20 hours ago | 439 comments
27.
How we made hit video game Prince of Persia (theguardian.com)
247 points by msephton 2 days ago | 95 comments
28.
Encrypted Spaces An architecture for collaborative applications (encryptedspaces.org)
44 points by _____k 6 hours ago | 5 comments
29.
New privacy frontier: Europe eyes crackdown on smart glasses (politico.com)
44 points by 1vuio0pswjnm7 2 hours ago | 27 comments
30.
Show HN: Script to bulk delete Claude chats from the web UI (github.com)
41 points by ML0037 4 hours ago | 12 comments