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1.
CRISPR tech selectively shreds cancer cells, including "undruggable" cancers (innovativegenomics.org)
533 points by gmays 6 hours ago | 140 comments
2.
I Am Not a Reverse Centaur (blog.miguelgrinberg.com)
198 points by ibobev 3 hours ago | 134 comments
3.
Swift at Apple: Migrating the TrueType Hinting Interpreter (swift.org)
35 points by DASD 1 hour ago | 10 comments
4.
How to setup a local coding agent on macOS (ikyle.me)
147 points by kkm 3 hours ago | 50 comments
5.
Malware developers added nuclear and biological weapons text to to their spyware (twitter.com)
206 points by marc__1 1 day ago | 140 comments
6.
Pirates, a naval warfare game inspired by Sid Meier's Pirates (piwodlaiwo.github.io)
129 points by iweczek 4 hours ago | 55 comments
7.
Mmorpg World of ClaudeCraft, vibe coded with Fable 5 (worldofclaudecraft.com)
10 points by beatthatflight 53 minutes ago | 2 comments
8.
Slightly reducing the sloppiness of AI generated front end (envs.net)
143 points by FergusArgyll 6 hours ago | 97 comments
9.
Palantir loses legal challenge against Swiss investigative magazine (ft.com)
27 points by sschueller 48 minutes ago | 2 comments
10.
Launch HN: BitBoard (YC P25) – Analytics Workspace for Agents (bitboard.work)
28 points by arcb 4 hours ago | 11 comments
11.
"Don't You Just Upload It to ChatGPT?" (correresmidestino.com)
186 points by speckx 3 hours ago | 161 comments
12.
Where Did Earth Get Its Oceans? Maybe It Made Them Itself (quantamagazine.org)
86 points by ibobev 5 hours ago | 50 comments
13.
A PDF that changes based on how its read (sgaud.com)
99 points by SarthakGaud 4 hours ago | 54 comments
14.
Cosmodial Sky Atlas (killedbyapixel.github.io)
21 points by memalign 3 hours ago | 1 comments
15.
Introduction to UEFI HTTP(s) Boot with QEMU/OVMF (blog.yadutaf.fr)
59 points by jtlebigot 6 hours ago | 17 comments
16.
There Is Life Before Main in Rust (grack.com)
53 points by mmastrac 1 day ago | 13 comments
17.
A dumpster arrived behind my university's library (yalereview.org)
142 points by mooreds 7 hours ago | 120 comments
18.
Maxproof (arxiv.org)
121 points by ilreb 9 hours ago | 10 comments
19.
Can I Buy Your KV Cache? (arxiv.org)
5 points by MediaSquirrel 1 hour ago | 3 comments
20.
If you are asking for human attention, demonstrate human effort (tombedor.dev)
1437 points by jjfoooo4 22 hours ago | 450 comments
21.
Hazel (YC W24) Is Hiring a Full Stack Engineer (ycombinator.com)
1 points by augustschen 8 hours ago
22.
A Call to Action: Stop the FCC's KYC Regime (blog.lopp.net)
295 points by FergusArgyll 6 hours ago | 191 comments
23.
Show HN: StackScope – I crawled over 40k indie launches to see what they ship (stackscope.dev)
35 points by datafreak_ 6 hours ago | 12 comments
24.
WASI 0.3 (bytecodealliance.org)
211 points by mavdol04 7 hours ago | 83 comments
25.
You can power on a Mac remotely (jeffgeerling.com)
28 points by speckx 5 hours ago | 18 comments
26.
Law Enforcement's "Warrior" Problem (2015) (harvardlawreview.org)
73 points by bookofjoe 4 hours ago | 58 comments
27.
Looking Forward to Postgres 19: It's About Time (pgedge.com)
111 points by xngbuilds 4 hours ago | 33 comments
28.
Most Beautiful Will Ever Made (1936) (paperspast.natlib.govt.nz)
9 points by cf100clunk 3 hours ago | 1 comments
29.
A jacket that harvests drinking water from the air (news.utexas.edu)
154 points by ilreb 22 hours ago | 96 comments
30.
Encrypted Spaces An architecture for collaborative applications (encryptedspaces.org)
54 points by _____k 9 hours ago | 7 comments