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by sabarjp
3973 days ago
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This experiment is quite flawed, at best. At the minimum: - Oversimplified models of biochemistry (way, way more complex than insulin = fat)
- Sample size of 2 trials (leaving one result)
- No measure of insulin (not a one-to-one relation to blood glucose, also released in complex cycles)
- No control of meal time (blood glucose varies)
- No control of meal contents (assuming both meals are equal in content)
- No control of fasting time (blood glucose varies) I have had to treat diabetes in cats so I got quite proficient with measuring blood glucose levels. Even when you control every single factor as much as possible (animal eats the same amount, at the same time, every day), blood glucose varies wildly. Non-diabetics have the same massive variance, as I have done blood glucose curves to myself and to others. This experiment is unfortunately pretty much useless. The body is a very complex organic machine with lots of parts that evolved independently of each other. There aren't neat little one-to-one relationships that can be tested easily. It is full of genes that modify genes that modify genes that secrete hormones that modify pathways and brain patterns and so on. |
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"Oversimplified models of biochemistry" - when insulin binds to an insulin receptor on a fat cell, the fat cell activates LPL, translocates GLUT4 to the cell membrane, and inhibits HSL. What else am I missing?
"No measure of insulin" -- insulin is not as easy to measure using off-the-shelf devices. If one meal leads to higher blood glucose levels than another, especially if it is vastly higher, it is a reasonable working assumption that it elicits a greater insulin response.
"No control of meal time" -- both meals were dinners.
"No control of fasting time" -- I ate the same amount during the day prior to each meal. Activity levels were also similar.
Re: widely varying blood glucose levels, in my own experience, it is very rare to see a meal cause a blood glucose concentration reach 150 mg/dL. This is very, very high amongst my meals and only happens with meals like this.
The following meal would most certainly be nowhere near 150 mg/dL no matter the time of day: vegetables (kale, broccoli, cauliflower), black beans, sardines, and avocado.