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MANPADS are an issue but the A-10 was designed with their deployment in mind. The most important feature of a MANPAD system is it's ability to be carried by 1-2 soldiers. That places an upper bound on the weight of a system which limits the size of the missile's warhead.

Most MANPADS have warheads weighing less than 5kg, a few kg of HE is enough to cause significant damage but the A-10 was built to fly with half a wing, one engine, one rudder/elevator assembly, and a mountain of shrapnel stuck in the pilot's armored tub. MANPADS will get a mission kill on an A-10 but they aren't powerful enough to bring one down the majority of the time.