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A major milestone has been reached in our Brain Preservation Prize (blog.brainpreservation.org)
64 points by porejide 4049 days ago
4 comments

Note that this approach should be compared with cryonics, which attempts to vitrify the brain and preserve it in a glass-like state at liquid nitrogen temperatures:

http://www.alcor.org/

Personally I have some reservations about the plastination approach to personal longevity. Depending on your philosophical views on the nature of consciousness, it may be that under this procedure you would die and cease to exist, while some future emulation of your brain thinks it is you -- i.e. biological-you and future-emulated-you are two separate people that just share memories.

It is however interesting science and may be a short-cut path to getting necessary scanning resolution for whole brain emulation.

Isn't this the same as saying you are a different person every morning and that the person that went to sleep and the person that woke up are separate people?
No, its very probably not the same. The brain doesn't shut off when you go to sleep. It keeps going, it keeps doing it's stuff, messing with memories, thoughts, all the bodily functions and a whole extra stuff that we don't know too well, but which probably still makes you you. Killing that brain and then simulating it somewhere else is not the same.
More importantly, does anyone suggest that running the original brain and the copy doesn't result in two separate diverged intellects? If running two results in separate consciousnesses then obviously they are not the same.
I don't think that follows. If "your" consciousness is just the consciousness that has a continuity of memory with a previous version of you, then the two copies would both be you, but they would not be one another.
Let's say that I a suitably advanced fMRI is developed that is able to map out the connectome non-destructively, I use this device on you to create a copy of your mental state, and then let you go about your day. At some point later I turn on a whole-brain simulation from this data. What do you, the you-that-walked-into-the-scanner expect to experience?
That's obvious to me, but I've learned that it's not obvious to everybody. It's an instance of the mind projection fallacy that your or I think that is a simple obvious truth but others think the opposite is just as intuitive. I sometimes wonder if different people have different experiences of consciousness and self-identity...
What about what happens during hypothermia? Both during Cardiopulmonary bypass and cold water immersion, the brain is cooled enough that activity stops.
I personaly subscribe to that opinion. Even if the change is negligible. This is why I would like to be sober and conscious in case of any uploading.
To recap for everyone joining the conversation afresh: our intuitions about selfhood, continual consciousness, and personal identity probably don't make any sense at all if applied to this kind of question. The right thing to do isn't trying to repair the intuitions, but instead trying to figure out which of the unintuitive possibilities we happen to like.
What about the Ship of Theseus paradox applied to brains?

If you don't 'feel' your death but all parts in your brain are eventually replaced by 'equivalent' ones, are you still yourself?

Buddhism has some interesting views on the nature of consciousness and "selfness". I think this is an interesting opportunity to think about what being "you" really means.
One step closer to me being able to spin up multiple instances of my brain to work on my side project and play video games with.
Please add a load balancer too. I hope we can have an interface like amazon ec2, but for brains
That would have been a somewhat less ridiculous explanation for The Matrix. "Oh, those vats full of humans? They're our neural network cloud".
Yes, and considering that The Fall of Hyperion was published in 1990, that scenario should have been obvious to the Wachowskis.
It was actually what they intended, before the execs told them audiences wouldn't understand it.
Not surprising, considering I had relatively techie friends that were absolutely mindblown by concepts like pervasive virtual reality (never mind taking the next step beyond the Matrix to "uploading"). I was utterly taken aback at the realisation of just how foreign ideas like that were to people that weren't steeped in SF.
"Humans are used as batteries."

"Humans are used as computer chips."

Neither statement really makes any sense without some creative thinking. Execs are weird.

That postulates that everyone's brain is worth simulating.

In the beginning, only the most "valuable" neural mappings will be worth the computing time required to simulate them. And rights! Does a simulated neural network of a human being have the same rights as a human being? One couldn't argue that simply because the underlying processor is silicon-based instead of carbon-based rights are lost.

Many philosophical questions to answer.

Or spin up an instance with the 'lazyness' region deactivated.
We just has a plastination vs. cryonics debate (https://news.ycombinator.com/item?id=9595853) which might be of interest here.
I am glad progress is being made here, but until we can avoid the destruction that occurs in the last 24 hours of expected death (eg cancer), or the damage that occurs with unexpected death (eg heart attack or trauma) from sitting at room temperature for hours after death, then all we are going to be preserving is grey mush.
There has to be enough information left over to reconstruct a person in "high enough fidelity" (whatever we may decide that means in the future).

A brain just sitting there for hours after death at room temperature isn't idea - however, there is some good news in the area. It turns out that the most destruction happening to a brain after an ischemic episode is actually due to a cascade triggered by eventual re-perfusion. Since the dead brain is never re-perfused, this cascade is never triggered. Cellular decay after death makes a biological re-animation infeasible, but speaking as someone who did prepare a lot of neuro slides at uni, it takes more than a few hours for the structure itself to decay heavily, so we should be good for a scan/upload scenario.

Pertaining to the article, the first hours after death are nowhere near as problematic to the brain's information content as the plastination procedure they're using!

Brain trauma before death is another matter. Since we don't have the capability to create backups or checkpoints of our neuronal structure, what's physically destroyed is simply lost beyond recovery. However, for example in aggressive brain cancers, a functional copy of the person might still be recovered in principle even if their neocortex was severely compromised, as long as the actual data is still there.

If people learn to take regular backups this wouldn't be a problem.
If only this were possible :(
Will those backups be you? What if one of those backups activated on accident? Would you kill it? Or should it kill you?
Depending on your outlook on life, if the backup is you, don't you already know the answer?
I agree. But I also think this work (and future work like it) will help with that; having convincing proof that a preservation process works will make it easier to get obstacles to prompt preservation out of the way.
You're assuming this "grey mush" can't be recovered. We don't actually know that. A sufficiently advanced AI should be able to recover a person from way less.
You're assuming the phrase "a sufficiently advanced AI" answers anything at all.

Presumably you're assuming if the information is there at all - if the necessary data hasn't been scrambled beyond the noise floor of the scrambling process - then there's something for magic (because you're really talking about magic here) to work with.

So, please (a) set out your claim with precision (b) back up your claim.

* What is the information you need to recover?

* To what degree is it scrambled?

* What of it is scrambled below the noise floor of the process?

* How do you know all this? (wrong answer: "here's a LessWrong/Alcor page." right answer: "here's something from a relevant neuroscientist.")

For comparison: even a nigh-magical superintelligent AI can't recover an ice sculpture from the bucket of water it's melted into. It is in fact possible to just lose information. So, since you're making this claim, I'd like you to quantify just what you think the damage actually is.

I'm quite sure I've read somewhere that information cannot be lost in the absolute sense, lost to us: yes, lost irrevocably and irrefutably: no.

In that sense, 'a sufficiently advanced AI' is not magic, because when people say that they definitively have something in mind, at least the people I often discuss this with do.

In short: if you're smart(fast, precise, determined) enough to look at the individual molecules of a puddle of brain-goo. And if you can infer the way it has collapsed by ray tracing those molecules back through how they collided with each other/the walls of your mold then it should be possible to reconstruct the spatial form of the brains at least. That's a pretty big IF obviously, but equally obviously not impossible. If only you can look deep/far/fast enough.

If you want to be theoretical about it, then yes. There is probably an upper bound on how smart/big an AI mind can possibly be. And thus there is a limit on how much information it can extract from arbitrary systems. So I agree with your assertion that there is information that even the smartest of all AIs cannot possibly reconstruct, but I'm not sure that the brain is such a structure.

Any justification about why/how 'a sufficiently advanced AI' could come about is more questionable.

Many knowledgeable people are making guesses based on our current understanding of intelligence/computation/AI, and then extrapolating. The paradoxical thing is that on the one hand AI-doomsday speakers tell us no to anthropomorphise (for good reasons) with the motives of an AI, but on the other hand apply human reasoning/understanding to predict such machines/patterns.

> I'm quite sure I've read somewhere that information cannot be lost in the absolute sense, lost to us: yes, lost irrevocably and irrefutably: no.

This is probably not quite at the requested standard of backing up a claim, and sounds very like "but you can't prove it isn't true!" But I'm not the one making a claim.

In any case, please back up your claim. What is "the absolute sense"? How does it differ from "in a practical sense", with examples?

> In short: if you're smart(fast, precise, determined) enough to look at the individual molecules of a puddle of brain-goo. And if you can infer the way it has collapsed by ray tracing those molecules back through how they collided with each other/the walls of your mold then it should be possible to reconstruct the spatial form of the brains at least. That's a pretty big IF obviously, but equally obviously not impossible. If only you can look deep/far/fast enough.

Noise floor. In this case, thermal noise.

Also, you literally can't know that much about all the molecules in your puddle of goo. (Heisenberg.) We do not live in a Newtonian universe.

http://en.wikipedia.org/wiki/Entropy_in_thermodynamics_and_i...

http://phys.org/news/2014-09-entropy-black-holes.html

http://phys.org/news/2014-09-black-hole-thermodynamics.html

Ben Crowell, phd in physics:

http://physics.stackexchange.com/questions/83731/entropy-inc...

The reason I didn't/don't back up those claims is because I'm really not knowledgeable about those subjects. I'm not sure what good sources are/how legitimate they are, but I have read it one day. Even if I cannot interpret the technical jargon behind it and/or give more nuance to my claim due to a low understanding of the subject.

Given a bit of googeling to "can information be lost", "conservation of information" one finds the articles I linked to above.

But you have dodged my refutal of your initial claim, the one I was really responding to, that: 'sufficiently advanced AI' is not just a stop-gap-word for magic. Because in this case it doesn't stand for "I don't know how or why but this and this", but instead it stands for "I don't know why(in the motivational sense), but given a bigger brain one can use and interpret finer instruments, which in turn enables us to extrapolate further back in time".

>I'm quite sure I've read somewhere that information cannot be lost in the absolute sense,

Quantum information is, in some decently well-regarded theories, a conserved quantity. Classical information is not, in any major theory.

>In short: if you're smart(fast, precise, determined) enough to look at the individual molecules of a puddle of brain-goo. And if you can infer the way it has collapsed by ray tracing those molecules back through how they collided with each other/the walls of your mold then it should be possible to reconstruct the spatial form of the brains at least. That's a pretty big IF obviously, but equally obviously not impossible. If only you can look deep/far/fast enough.

Again: classical information is not a conserved quantity. A puddle of brain-goo will likely tell you more than a puddle of non-brain goo about the person who used to be that brain, but there is a very strong limit to what it can tell you. You cannot, so to speak, extrapolate the universe from one small piece of fairy cake.

(Disclaimer: I have previously donated to the Brain Preservation Foundation precisely because I think the issue deserves investigation by mainstream, non-wishful scientists so that people who want to... whatever it is they're planning on, can do it.)

>Many knowledgeable people are making guesses based on our current understanding of intelligence/computation/AI, and then extrapolating. The paradoxical thing is that on the one hand AI-doomsday speakers tell us no to anthropomorphise (for good reasons) with the motives of an AI, but on the other hand apply human reasoning/understanding to predict such machines/patterns.

The thing about "sufficiently advanced AI" is that it dodges the basic issues. A sufficiently advanced AI is just a machine for crunching data into generalized theories. It can only learn theories in the presence of data. Admittedly, the more data it gets from a broader variety of domains, the more it can form abstract theories that give usefully informed prior knowledge about what it can expect to find in new domains. But if it can use detailed knowledge about brains-in-general to reconstruct a puddle of brain-goo into a solid model of a human brain, solid enough to "make it live", that's not because of some ontologically basic "smartness" about the AI, it's because the AI has the right kind of learning machinery for crunching data about specific and general things together to allow it to learn and utilize very large sums of domain knowledge. These sums could possibly larger than any individual human might obtain in the course of a single 20-year education, from kindergarten to PhD, but the key factor in "AI's" understanding of the natural sciences will ultimately be experimental data and domain knowledge derived from experimental data.

Sure it can. Look at a photograph, make a mould and find a freezer :P
If it's a godlike AI it can simulate humankind in reverse and resurrect everyone's consciousness before each person's death.
That is absolute bunk that defies the basic principles of computational complexity and information theory in almost every possible way.
The problem is the information is encoded in the arrangements of the neural connections. Once your brain has reached the grey mush stage all those connection are lost.
Aren't neurons relatively sizable? I don't see why they would totally "decay" in a short time frame, but maybe it's because I'm ignorant.
Such AI will only be able to recover a gradient set of possible personalities depending on the percentage of missing data. Something like 1000000 of slightly different permutations of you.