[popeshoe]

My biggest problem moving to OSX (from mostly windows) was the idiotic apple UK keyboard layout (US keyboards might not be such a big deal, so this stuff might not apply) so I found myself having to download a regular UK keyboard layout (http://liyang.hu/osx-british.xhtml), and Karabiner (https://pqrs.org/osx/karabiner/) to make OSX behave properly with my normal keyboard with the pageup/down and home/end keys

Once I sorted that out it was a relatively pleasant experience.

You might also want to install SmoothMouse (http://smoothmouse.com/) which tames OSX's ferocious mouse acceleration curve, and reduces the delay between moving the mouse and the screen updating to be imperceptible