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by Luc
4074 days ago
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I have only scanned it, but probably in here:
http://jpsl.org/archives/history-and-implications-testing-th... "Lasagna [157] commented that once a chemical is known to cause birth defects in humans, an animal species or strain can usually be found that will replicate the response, but that this is not the same as prospectively predicting this response." |
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Lucey and Behrman. 1963. Thalidomide: effect upon pregnancy in the rhesus monkey. Science 139:1295-1296.
Hendrickx, Axelrod and Clayborn. 1966. 'Thalidomide' syndrome in baboons. Nature 210 (5039):958-959.
"Delahunt and Lassen induced typically malformed foetuses in four of seven pregnant Cynomolgus monkeys which were treated after implantation had already occurred"
Hendrickx, A. G., and L. Newman. 1973. Appendicular skeletal and visceral malformations induced by thalidomide in bonnet monkeys. Teratology 7 (2):151-159. doi:10.1002/tera.1420070206.
Please note the year of the articles. The studies with monkeys were made after the drug was distributed in many countries and thousands of babies without legs and arms started to born, not before.