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by m-photonic 4076 days ago
The Pythagorean comma is nothing to worry about -- it's tiny and more or less negligible. It's the syntonic comma that's the killer.

The fifths in equal temperament are completely fine, but the thirds are really quite a ways off from the harmonic 5/4 major third. I would recommend experimenting with the traditional meantone tuning system if you're interested in this -- it offers almost as much flexibility as equal temperament (with 6 adjacent keys on the circle of fifths being free of wolf intervals), and it lets you play with "real thirds".