| Just a couple of notes. The "Rizos et al. in JAMA 2012;308:1024-1033" refers to the article: Rizos E. C., Ntzani E. E., Bika E., Kostapanos M. S., Elisaf M. S. (2012). Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events. JAMA 308, 1024–1033 10.1001/2012.jama.11374 The article can be read for free here:
http://jama.jamanetwork.com/article.aspx?articleid=1357266 The reason for using .006 is stated in the article: "Within each assessed outcome, we adopted a level of statistical significance adjusted for multiple comparisons testing by a factor of 8 equaling the number of overall and subgroup analyses performed using the 2 measures of effect (RR and RD); thus, statistical significance was assumed at a P value threshold of .0063." P-value adjustments are fairly common [1], but I'm not smart enough to say if it was applicable in this case. Also, in the interest of full disclosure, it might be worth mentioning that Bill Harris is the President of OmegaQuant
Analytics [2], whose stated purpose is to "advanc[e] the science and use of omega-3 fatty acids to improve health." [1] http://stat.ethz.ch/R-manual/R-patched/library/stats/html/p.... [2] http://www.omegaquant.com/. He also seems to have a pre-canned response, which he pastes as comments to various sites. The pre-canned response is here: http://www.omega-3centre.com/images/stories/pdfs/harris_jama... |