[chmille4]

I figured I could add a little clarification to this comment.

* The human genome project created a "single" genome (thats not quite right, but close enough for this discussion). This was and is incredibly useful, but a single genome can only do so much. To answer population genomics questions (e.g. is this mutation common and therefore probably not disease causative) you need lots of people and the more the better.

* The 23andme dataset is not whole genome data, but instead some subset of genomic locations that they consider more interesting. Still valuable but not as much as whole genome data.

Also, for big whole genome datasets you can check out the 1000 Genomes Project, which has somewhere north of 2000 genomes. And there are many more big datasets in the works, which will continue to be incredibly useful!

[dluan]

Good clarification, amended my comment too. Although, the 23andme dataset is with live participants with genealogy data. That's a dimension HGP doesn't offer.

1000 Genomes looks great, but how is it funded? Also, how is the sequencing done? Presents a few more open variables, and 23andme is orders of magnitude larger.

[chmille4]

Absolutely, I meant to add above that the 23andme dataset has huge value due to its size. Also you bring up a good point about potential easy access to participants. If 23andme allows researchers to contact people who were of interest to their particular study and ask for more information, which could be as easy a questionnaire, that could be incredibly valuable. I don't agree with the above commenter that 23andme was a failure. Genomics is still incredibly young and we are just getting to the point where we can have an impact on the average persons life.

As for the 1000 genomes project, it was funded with government money (I think mostly the NIH, although the UK may have been involved too) therefore the data is free and open. The data was generated using illumina sequencers.

[jghn]

Worth noting that the sequencing was done at multiple centers, eg the broad institute