[vobios]

> Two drugs could be very safe on their own, but in combination could cause serious adverse events

That is true. My assumption was that only single compounds or previously tested combinations are suggested.

> Unless you are running a controlled clinical trial, I'm not sure anyone would trust the data.

I agree. I just meant it would be relatively easy to collect enough preliminary data to have a reasonable idea of how a proper clinical trial would go. It's not like going from an animal model to human trials or from a tiny cohort of late-stage patients to a larger more heterogenous group.

[refurb]

It's not like going from an animal model to human trials or from a tiny cohort of late-stage patients to a larger more heterogenous group.

Fair point. A retrospective analysis would provide some data. The problem is insurance companies have pretty high standards (at least for cancer drug that cost a lot)!