[dguaraglia]

Hi Matt, first I wanted to thank you for doing this. Cancer, and unfortunately the treatment for it, can be devastating. Anything we can do to improve that, is money well spent.

I had a few questions:

1) Does NotableLabs produce a standard pathological report for the oncologist before starting the tests? (I ask because in my experience that process can take weeks in a normal lab, so I wonder what's the feasibility of performing tests on a specimen after that long.)

2) Are there any challenges/differences when applying the drugs directly to the cells? Do the cells in a Petri dish behave differently from cells in the patient's body?

3) Out of curiosity, why did you choose brain tumors?

[M_NotableLabs]

1. Could you clarify your question on this please?

We won't be replacing the pathologist report for the oncologist. We also don't obtain the tumor after their analysis and report. Our testing will be running in parallel.

We produce our report using test results from the actual patient's living tumor that we obtain from the operating room. Pathologists embed the tumor cells in paraffin wax, which kills the tissue.

2. Yes there are challenges with applying the drugs because the cells are in an artificial environment outside of the body. We have improved the standard conditions the cells are tested in and will continue to develop methods to make the petri dish more like the patient's brain.

3. Initially brain cancer chose us, my dad passed away from the disease two weeks ago.

[dguaraglia]

I'm really for your loss Matt. As someone in remission (from a punier kind of cancer) myself, I'm thankful for people like you, looking for a cure. Thanks for your reply. My heart goes out to you and your family.