[Goladus]

Most well-designed applications will separate the administrative interface (configuration) from a programming interface (the API), even if the same langauge is used for each one. If you do this properly, most administrators are not going to care what language your configuration is in so long as it's clear and consistent.

In my experience, the main annoyance using programming languages for configuration is the need to use explicit string literals for every string in your file. List separators are another major source of clutter in configuration files, though this is theoretically not a problem in clojure. The second problem is the tendency to be undisciplined and allow too much program logic in configuration files resulting in complex and unclear relationships between options and behavior.

Personally I do all my configuration in yaml now. Even if I was using lisp I would use yaml whenever possible for configuration and static resource definitions, because yaml is very portable.