[icebraining]

Maybe

  sed -i 's/old certificate/new certificate/g' /usr/bin/dropbox

Used to work in some software.

EDIT: Matasano has a nice guide for bypassing OpenSSL cert pinning (for iOS apps, but the techniques should be more broadly applicable): http://chargen.matasano.com/chargen/2015/1/6/bypassing-opens...