[detaro]

Not GP, but: multiple windows and intuition. Generally, for ~20 tabs per window I still can tell pretty okay what is what, only large swabs of similar tabs (e.g. 10 ebay product sites) are a bit annoying. A tab switcher that shows the headlines would admittedly be helpful.

[scholia]

In Firefox, I either scroll quickly though readable tabs with the mouse-wheel, or click the right down-arrow for a text list of tabs, or start typing in the address bar of whichever tab I'm in. For example, if I type twi then the drop-down list offers Twitter, and I select "Switch to tab". That gets me to the half-dozen tabs I want to look at several times a day.

With those options plus tab groups, I find it pretty easy to handle several hundred tabs in Firefox, where Chrome was a nightmare. The drawback is that you just keep adding tabs ;-)