[lastofus]

I found Knockout to be a great middle ground for when "I can do this in jQuery, but it's gona be messy" and "I'm building a SPA".

It hits the sweet spot between easy learning curve, abstraction, and interacting with the DOM nicely.

Sadly, it's not as hip as React/Angular/Ember these days.

[muraiki]

I've also had a good experience using Knockout. I used it to add some interactivity to a largely static site, and then expanded its use to create a fairly complex management interface. It's easy to pick up with great interactive tutorials on the web site, and with component support in the latest version you can build some larger web apps.

Microsoft uses it their recent remake of their Azure portal; this page has a video on building large apps with Knockout: http://jbeckwith.com/2014/09/20/how-the-azure-portal-works/