[plq]

You can use Spyne[1]'s HttpRpc and JsonDocument protocols via Flask-Spyne[2].

You can actually use Spyne with Django as well[3] (and Spyne has a "general model serializer" that can be used with a lot less boilerplate than what's shown here).

Spyne supports a lot of protocols as well as persisting to a relational database via SQLAlchemy.

Disclaimer: I'm the author of spyne.

[1]: http://spyne.io

[2]: https://pypi.python.org/pypi/Flask-Spyne

[3]: https://github.com/arskom/spyne/tree/master/examples/django/...