[sbilstein]

Not really, you can achieve this using a Rails (or rails-like thing like Play) very easily and use in their built CSRF, SSL, etc. but this type of design also makes it easy to build from scratch (which may lead you down the path of reinventing things).

SPA + restful endpoints makes it easy to pick a library centric approach vs. a framework approach but it certainly does not preclude you from using a framework.

I guess people who disable javascript don't get to use your site...but I don't really care about that segment of the population.

[Diederich]

I've also found it easier to secure my apps. The attack surface seems to be much smaller.