[jimrandomh]

First of all, intermittent fasting is different from calorie restriction is different from prolonged fasting. Prolonged fasting is much more dangerous than the other two.

And second, what applies to healthy people, metabolically speaking, usually does not apply to people with diabetes. I did a Pubmed search before I posted my comment, and wasn't able to find a single example of prolonged fasting having even been tried in T2DM patients.

As someone with T1DM (the kind caused by autoimmunity, not the kind caused by obesity), my expectation is that a T2DM who tried this in an ICU would probably experience hypoglycemia and abort, while someone who tried it outside an ICU would probably die.