|
|
|
|
|
|
by m_mueller
4187 days ago
|
|
|
IANAB. From what I understand, DNA research seems to have lots of still low hanging fruits for simple mathematical models to achieve big breakthroughs. Yamanaka won a nobel price for cell reprogramming that simply came from neglecting the previous brute force method to find the correct molecule combination that lead to many years of Biologists trying out combination after combination. Instead he basically deduced it through simple modelling and applying the scientific method. A quick google has brought the following thesis, which bases some more modelling on Yamanaka in order to refine stem cell reprogramming [1]. From my point of view, the really outstanding work in biology currently rather comes from outsiders that break out of the usual methods of biologists, such as the applied mathematician Erez Lieberman Aiden who showed how genome folding works and actually has an important function (activating / deactivating regions in order to program cell functions), purely through mathematical modelling of the signals we can get out of current instruments and throwing HPC at it. I'm pretty sure the field would benefit greatly from more cross pollination from other fields. [1] https://www2.hu-berlin.de/biologie/theorybp/docs/dipl_scharp... [2] http://www.sciencemag.org/content/326/5950/289.short |
|
|