In the last 8 months, I have submitted 270+ job applications, received 3 interviews, got rejected by all three, none of which were high reputation companies.
Did you ask for anyone to look at your CV and help you improve it maybe? For what it's worth, I'm not in HR but I interview a lot of people and see a lot of CVs (not hiring currently though). You can send me your CV privately if you want some feedback.