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by fasteo 4206 days ago
Mitochondrial damaged human speaking (genetic cause, not antibiotics)

Hormesis is about dose. In these cases, the dose is just too high and our body is unable to cope with it.

In my case the damage is just below this threshold and my body has created a powerful antioxidant machinery [1] that is keeping me alive. In other cases of my disease, the burden - % of mutant mitochondria - is just too high [2] and sadly, the kids die when they are 3-4 years old.

[1] http://www.sciencedirect.com/science/article/pii/S1096719203...

[2] http://ghr.nlm.nih.gov/condition/leigh-syndrome