[ColinCera]

A few things I can recommend:

(1) Switch to the Colemak keyboard layout -- it significantly reduces the work your fingers have to do.

(2) Vary your mousing devices/behaviors. I love Kensington trackballs, and they're much easier on my wrist than a mouse, but after awhile I get pain in my thumb (because with a trackball you typically use your thumb to left-click rather than your index finger), so I switch back to a mouse for a few weeks. Vertical mice are also nice and I occasionally use one for a change. You can also move your mouse/trackball to the other side of the keyboard and use your non-dominant hand -- it takes a few days to rewire your brain, but it's another good way to change up your mousing behavior.

(3) Consider buying a USB numeric keypad, placing it on the non-dominant side of your keyboard, and using macro software to program the keys for common actions (e.g., scrolling).

[mstechfreak]

http://www.typingstudy.com/en-us_colemak-3/ This is a free typing tutor for those who want to learn to type with colemak ;)

[entreprenewb]

Clickable, for those like me that hadn't heard of Colemak: http://colemak.com/