Hacker News new | ask | show | jobs
by nmjohn 4213 days ago
Sometimes - but they ARE metabolized through the same pathway.

Essentially:

    Glucose ->[0] pyruvate ->[1] acetyl-coa -> TCA cycle
vs

    Fatty acids ->[2] acetyl-coa -> TCA cycle
The TCA is cycle is the actual main energy generating step.

Other times fat absolutely is converted to sugar. It all depends on the metabolic needs of the body and one building blocks are available, and what protein "workers" are able to use the ones that are available.

For example, fatty acid synthase converts acetyl coa back to a fatty acid [3].

[0] Glycolysis: http://en.wikipedia.org/wiki/Glycolysis

[1] pyruvate dehydrogenase: http://en.wikipedia.org/wiki/Pyruvate_dehydrogenase

[2] beta oxidation: http://en.wikipedia.org/wiki/Beta_oxidation

[3]: http://en.wikipedia.org/wiki/Fatty_acid_synthase

1 comments

None of your refs justify your claim that "fat absolutely is converted to sugar".
That wasn't my claim, please don't misquote me. What I actually said was "Other times fat absolutely is converted to sugar." There is a very significant difference.
So what are those "other times" and where is the evidence?