[vnuk]

http://www.duplicati.com/

Windows port of duply/duplicity. Client side encryption possible and you can use USB/NAS as target or S3 ...

[pbhjpbhj]

I looked at a range of backup solutions - http://alicious.com/cloud-backup-solutions/ - for a simple one-folder backup from a work computer. I too settled on duplicati.

Originally I was using it with Microsoft's online cloud storage (skydrive I think they were calling it, it's changed now due to TM action) but that stopped working and now I use gdrive instead (or whatever that is now, gapps storage or something).