[FraKtus]

MetaSynth is all about that, you can import visuals, draw over them, filter them and then go back to audio, MetaSynth is available since a very long time, it was first running on Mac OS 9. http://www.uisoftware.com/MetaSynth/index.php

[sneak]

This is what RDJ used to make the sounds in the b-side on Windowlicker.