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I did an "English for Engineers" course at uni (a misguided attempt at giving engineers a more rounded education - personally I was frustrated that they didn't let me take straight up Literature 101 - my roommate was an English major, and I must have written about half her essays for Lit 101, just because I found it interesting - averaged a distinction :D )

Anyway, Frankenstein was one of the cornerstone texts of that course, and you can clearly see many of the themes of later SF being developed by Shelley. We also read Dr Jekyll and Mr Hyde in that course, plus some early Australian SF (like Picnic at Hanging Rock). It was all pretty interesting, but a long way from the space opera that is one of the cornerstones of modern SF. I just don't feel like you can experience SF unless you've read some of the bigger more sweeping stuff, like Hyperion or Pandora's Star.