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by Animats 4292 days ago
Yes, it can be done, but the half-dozen or so LISP machines of the 1980s were not very successful. Price/performance was worse than compiled LISP on common CPUs.

There's no indication of hardware support for garbage collection. It would probably be more useful to have tag bits to support GC than a LISP-oriented instruction set, especially if it allowed concurrent GC.