It's really a hell. Average website over there is using at least 3 - 4 external domains for css, js, fonts and so. Getting a working website without nearly whitelisting many of them is highly improbable right now.
Sure. I used script blockers for a while. But after having to whitelist a huge number of them and loosing very long and precious time, I gave in. I do not put sensitive and important data on my computer. (Actually I was not doing that for a very long time even before giving in.) I always work on remote hosts.
Therefore I treat my desktop as a security research one. Of course I would not do that on my desktop I were really working with crackme binaries ;)
Regarding "I do not put sensitive and important data on my computer" and "I always work on remote hosts", I must respectfully disagree. Never mind the fact that you set a bad example for newbies, being so caviler with your own safety harms the security of the rest of us. Downloading and executing random software off the Internet---the raison d'être of modern web browsers---is a good way to get owned. Just because you don't use your computer for anything important doesn't mean that it cannot be compromised and used to attack me. Plus, if you use your computer to log into other computers to do real work, then your computer is extremely important! A successful compromise would give attackers all the same remote access you have. Admittedly, that's not what your everyday, ordinary malware is after, but it's the principal of the thing that bothers me.
Additionally to then there's also the various things that track identity and behaviour. Tell me what you search and click, and I'll tell you what you think? (That's not fixed with a simple add-on of course.)
For most people Ghostery and AdBlock Edge are good enough. I'm a pretty conservative, default-deny kind of hacker, so the results of my cost-benefit analysis are a little... different... than most. :)