Generally yes, although the cashier might be momentarily confused when the machine prompts her to get a signature since everyone else just uses their pin.
The only place it won't work at all is self-service kiosk.
It ought to, since some European customers have chip-and-signature cards for various reasons. There's no guarantee that shop employees will be properly trained on how to handle it though.
The only place it won't work at all is self-service kiosk.