[troym]

> I'm pretty sure the side effects would be utterly intolerable even at half of that dose.

I'm absolutely sure. My son takes methylphenidate for traumatic narcolepsy and hyperphagia. At ~60 kg with a 30mg dose, he's got tremors, sweats, chattering teeth, etc.

I can only assume that the researchers have reason to study using these higher doses in mice, but 1mg/kg and 10mg/kg was the first thing that caught my eye. Neurological degeneration seems entirely plausible when you're frying a brain with speed (so to speak).