Obviously, but enough to base their bike purchase around that aspect? Most people I know who ride a lot and spend up on their bikes use them primarily for commuting (they know the route) or exercise (know the route or are riding with friends who know). Again, sample set is just those I know, but they still drive if they're heading to a meeting or event at a new location.
Well, sample size of one but I ride bikes to new locations. However, I have my phone's GPS in case I get lost. It helps a lot that the city I live in has a good bike share system and is fairly compact, so cycling is often the fastest option. I don't own a car, either, so I might not be the ideal respondent to your question.