I actually really enjoyed Dr. Pulaski, but I'm pretty aware I'm in a small group on that one. She was just so damn surly, which I thought brought a nice contrast to the rest of the cast.
I guess I have mixed feelings about her. She was definitely a character, and I give her credit for that. She was not out to win a popularity contest, or to be Miss Congeniality. She was gruff, old fashioned, and smart. Sort of like McCoy, but without the charm. But I just didn't buy her Luddite tendencies. Her treatment of Data bordered on cruel, even if I understand that sometimes she was doing it to make a point, or to test him in certain ways. But I just didn't get where it came from. It felt odd. And I know this isn't necessarily fair to Pulaski, but seeing as how Data is so gosh-darned lovable, her antagonism towards him makes her unlovable by association. It's like having a character whose defining traits include being mean to puppies. It's just...hard to win people over if you're going to be that person.
She's grown on me over the years. She's definitely a more interesting person than Dr. Crusher, but I think she was also too much of an homage to Bones from TOS.
I recently went back and watched some TOS and was really surprised to see young her on the show.